anna 2017 logo

ANNA 2017

Advances in Noncanonical Nucleic Acids

Program

Thursday, October 26, 2017.

Venue: Vila Bled

12:00 – 14:00

Registration and welcome

14:00 – 14:30

Opening remarks: Janez Plavec, Head of NMR Centre,

Afternoon session

14:30 – 15:00

Jyoti Chattopadhyaya: How RNase HI (E. coli) promoted site-selective hydrolysis works on RNA in duplex with carba-LNA and LNA substituted antisense strands in the antisense strategy?

15:00 – 15:30

Kazushi Kinbara: Monodisperse Engineered PEGs for Biorelated Applications

15:30 – 16:00

Masayasu Kuwahara: Simple Method for Various Biomarker Detections

16:00 – 16:30

Coffee break

16:30 – 17:00

Piet Herdewijn: Non-canonical nucleobases in vivo

17:00 – 17:30

Lukas Trantirek: Exploration of nucleic acid structure under physiological conditions in vivo using in-cell NMR spectroscopy

17:30 – 18:00

Marie-Paule Teulade-Fichou: Localizing G4 ligands in cells: where is the drug gone?

19:00

Welcome reception, Restaurant Špica, Bled

Friday, October 27, 2017.

Venue: Vila Bled

Morning session

9:00 – 9:30

Muthiah Manoharan: Chemically modified siRNAs for human therapeutics

9:30 – 10:00

Mateus Webba da Silva: Development of Tools for Rapid Characterization of Canonical G-quadruplexes

10:00 – 10:30

Satoru Nagatoishi: Thermodynamics and kinetics of the interaction between G-quadruplex aptamer and protein

10:30 – 11:00

Coffee break

11:00 – 11:30

Dongsheng Liu: DNA Hydrogels and their application in 3D Bioprinting

11:30 – 12:00

Shigeori Takenaka: Naphthalene diimide derivatives as novel tetraplex DNA ligand Shigeori Takenaka

12:00 – 12:30

Jurij Lah: Why a human telomere repeat DNA fragment folds into different G-quadruplex structures?

12:30 – 14:00

Lunch & Poster session, Vila Bled

Afternoon session

14:00 – 14:30

Naoki Sugimoto: “To B or not to B” in Nucleic Acids Chemistry

14:30 – 15:00

Radek Marek: Designing novel building blocks of nucleic acid quadruplexes

15:00 – 15:30

Chaoyong Yang: Evolving Aptamers for Bioanalysis and Biomedicine

15:30 – 16:00

Coffee break

16:00 – 16:30

Luigi Xodo: Guanine oxidation in KRAS promoter and design of therapeutic decoy oligonucleotides

16:30 – 17:00

Gilmar Salgado: Biophysical characterization and ligand binding of a polymorphic G-Quadruplex from the KRAS Proto-Oncogene Promoter Region

17:00 – 17:30

Hisae Tateishi-Karimata: Transcriptional regulation by DNA structural changes responsive chemical environments in cells during tumor progression

19:00

Conference dinnerBled castle

Saturday, October 28, 2017.

Venue: Vila Bled

Morning session

9:00 – 9:30

Jean-Louis Mergny: Quadruplexes are everywhere

9:30 – 10:00

Antonio Randazzo: Known DNA G-quadruplex ligands: first evidences of an unexpected i-motif binding activity

10:00 – 10:30

Vojč Kocman: AGCGA-quadruplex core architecture and the duplex pre-fold model

10:30 – 11:00

Coffee break

11:00 – 11:30

Claudia Sissi: Naphthalene diimides and DNA: a variegate friendship

11:30 – 12:00

Viktor Viglasky: Non-canonic structural motifs and DNA supercoiling

12:00 – 14:00

Lunch, Vila Bled

14:00 – 18:00

Individual discussions