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ANNA 2018

Advances in Noncanonical Nucleic Acids

Program

Thursday, October 25, 2018.

Venue: Hotel Bernardin

12:00 – 14:00

Registration and welcome

14:15 – 14:30

Opening remarks: Janez Plavec, Head of NMR Centre

 

Afternoon session


Chair: Primož Šket

14:30 – 15:00

Naoki Sugimoto: “To B or not to B” in Nucleic Acids Chemistry (2)

15:00 – 15:30

Valerie Gabelica: Thermal Denaturation of DNA G-Quadruplexes and Their Complexes with Ligands: Thermodynamic Analysis of the Multiple States Revealed by Mass Spectrometry

15:30 – 16:00

Anita Kotar: Structure of kit* G-quadruplex in promoter of c-KIT gene

16:00 – 16:30

Coffee break

16:30 – 17:00

Katherine Seley-Radtke: “Flex-nucleos(t)ides – a strategic approach to broad-spectrum antiviral therapeutics"

17:00 – 17:30

Masayasu Kuwahara: Thioflavin T derivatization: Creation of fluorescence indicators for various targets

17:30 – 18:00

Jasna Brčić: Structure of two G-quadruplexes formed by oligonucleotide with four d(G4C2) repeats: insights into structural polymorphism

19:00

Welcome reception, Restaurant Pavel, Piran

Friday, October 26, 2018.

Venue: Hotel Bernardin

 

Morning session


Chair: Zhen Xi

9:00 – 9:30

Piet Herdewijn: Phosphonate nucleosides and oligonucleotides

9:30 – 10:00

Masayuki Fujii: Chemistry and Biology of Nucleic Acid Conjugates as Therapeutic Agents

10:00 – 10:30

Yasuhiko Yamamoto: Deoxyribozymes Composed of Heme and G-quadruplex DNAs

10:30 – 11:00

Coffee break

11:00 – 11:30

Antonio Randazzo: Multivariate evaluation of the influence of pH and cation on i-motif DNA structure formation

11:30 – 12:00

Shigeori Takenaka: Detection by DNA tetraplex and detection of DNA tetraplex in a living cell

12:00 – 12:30

Liliya Yatsunyk: Biophysical and structural investigations into CAGAGG repeats associated with cancer

12:30 – 14:00

Lunch, Hotel Bernardin

 

Afternoon session


Chair: Viktor Viglasky

14:00 – 14:30

Katrin Paeschke: The missing link between G-quadruplex and DNA repair – Zuo1?

14:30 – 15:00

Trantírek Lukáš: The other G-hairpins

15:00 – 15:30

Marie-Paule Teulade-Fichou:Benchmarking G4 ligands: from G4 binding in vitro to cellular evaluation using Proximity Ligation Assay (PLA).

15:30 – 16:00

Coffee break

16:00 – 16:30

Claudia Sissi:DNA structural elements as potential target for regulation of gene expression

16:30 – 17:00

Jean-Louis Mergny: Quadruplexes are everywhere… but where exactly?

17:00 – 17:30

San Hadži: Why AGCGA repeat DNA sequence folds into tetrahelical structure?

19:00

Conference dinner, Mahnič, Dragonja

Saturday, October 27, 2018.

Venue: Hotel Bernardin

 

Morning session


Chair: Naoki Sugimoto

9:00 – 9:30

Zhen Xi: Gene Nanovector through Branch-PCR

9:30 – 10:00

Viktor Viglasky: Non-canonic structure extruded in long-range DNA

10:00 – 10:30

Shuntaro Takahashi: Structural dynamics of RNA aptamer analyzed by volumetric approach

10:30 – 11:00

Coffee break

11:00 – 11:30

Chaoyong Yang: Bioinspired Engineering of Multivalent Aptamer-Functionalized Nanointerface to Enhance Capture and Release of Circulating Tumor Cells

11:30 – 12:00

Mojgan Djavaheri-Mergny: ATM functions as a linchpin between senescence, apoptosis and autophagy upon treatment of cancer cells with the G-quadruplex ligand 20A

12:00 – 14:00

Lunch, Hotel Bernardin

14:00 – 18:00

Individual discussions