Program

Thursday, October 17, 2019.

12:00 – 13:00

Registration and welcome

13:15 – 13:30

Opening remarks: Janez Plavec, Head of NMR Center

Afternoon session

Chair: Antonio Randazzo

13:30 – 14:00

Katherine Seley-Radtke: Rational (and sometimes irrational!) strategies in nucleoside drug design

14:00 – 14:30

Daniela Montesarchio: The intriguing world of G-quadruplex-based aptamers: V7t1, an anti-VEGF aptamer, as a case study

14:30 – 15:00

Masayasu Kuwahara: Ultra-High Sensitive Simple Test Methods for Various Biomarkers

15:00 – 15:30

Zhen Xi: Gene Nanovector by Branch-PCR for Potential Tumor Control

15:30 – 16:00

Coffee break

16:00 – 16:30

Katrin Paeschke: Zuo1 recognizes G4 structures and supports binding of Nucleotide Excision repair factors

16:30 – 17:00

Sara Richter: ZNon-canonical nucleic acids in viruses: presence, function and targeting

17:00 – 17:30

Tamaki Endoh: Conformational Dynamics of the RNA G-Quadruplex and its Effect on Gene Expressions

17:30 – 18:00

Stase Bielskute: Human Telomeric G-quadruplex structures under oxidative stress

            19:00

Welcome reception , Jelenov Greben, Olimje

Friday, October 18, 2019.

Morning session

Chair: Naoki Sugimoto

9:00 – 9:30    

Marie-Paule Teulade-Fichou: DNA-interactive Macrocyclic Compounds: From Selectivity to Promiscuity

9:30 – 10:00  

Ramon Vilar: G4 DNA imaging with optical probes based on changes in emission lifetime

10:00 – 10:30

Shigeori Takenaka: Cyclic naphthalene diimde dimer to recognize guanine-quadruplex cluster

10:30 – 11:00

Coffee break

11:00 – 11:30

Luigi Xodo: Targeted cancer therapy: G4 ligands repressing translation

11:30 – 12:00

Gilmar Salgado: Structure of Multiple G-quadruplexes in equilibrium in KRAS Nuclease Hypersensitive Element sequence

12:00 – 12:30

Claudia Sissi: Non-canonical nucleic acid structures: which one?

12:30 – 13:30

Lunch, Hotel Atlantida

Afternoon session

Chair: Katrin Paeschke

13:30 – 14:00

Lukas Trantirek: Making sense of G-quadruplex polymorphism

14:00 – 14:30

Viktor Viglasky: Small local changes cause a great effect on global DNA

14:30 – 15:00

Hisae Tateishi-Karimata: Effect of RNA structures on RNA and RNA/peptide accumulation in repeat-expansion disorders

15:00 – 15:30

Chaoyong Yang: Molecular Evolution of Aptamers for Liquid Biopsy

16:00 – 17:30

Excursion: Rogaška Glassworks

            18:00

Conference dinner, Strmol Manor, Rogatec

Saturday, October 19, 2019.

Morning session

Chair: Sara Richter

9:00 – 9:30    

Naoki Sugimoto: "To B or not to B" in Nucleic Acids Chemistry (3)

9:30 – 10:00  

Roberto Improta: Shedding light on Guanine Quadruplexes and Guanine derivatives by Quantum Mechanical calculations

10:00 – 10:30

Jurij Lah: What is the origin of heat capacity increment in DNA folding?

10:30 – 11:00

Coffee break

11:00 – 11:30

Takehiko Wada: Development of high sensitive and high time-resolve circular dichroism (CD) measurement system

11:30 – 12:00

Valerie Gabelica: Circular Dichroism of G-quadruplexes in silico and in vacuo

12:00 – 12:30

Antonio Randazzo: Multivariate data analysis of CD and UV spectra of i-motif DNA tructures: an ongoing study

12:30 – 14:00

Lunch, Hotel Atlantida

14:00 – 18:00

Individual discussions