Marko Trajkovski
Ph.D.
marko.trajkovski@ki.si
(01) 47-60-505
Marko Trajkovski was born on 6th April, 1984, in Brežice, Slovenia. He received his B.Sc. degree in biochemistry at University of Ljubljana, Faculty of Chemistry and Chemical Technology in 2008 with thesis entitled ‘Studies of cation interactions with DNA aptamer of thrombin’, that also won him a prize on 38th Krka’s awards. From 2008 to 2013 he was involved in research activities as a PhD student working under mentorship of Professor Dr. Janez Plavec at the Slovenian NMR Centre, National Institute of Chemistry, Ljubljana, Slovenia. In 2011 he received award for best poster presentation by a young researcher at the "XVth Symposium on Chemistry of Nucleic Acid Components", Český Krumlov, Czech Republic. In 2013 he received title D.Sc. at University of Ljubljana, Faculty of Chemistry and Chemical Technology by elaborating Ph.D. thesis entitled ‘Folding and structures of DNA G-quadruplexes’, for which he received Krka’s prize and Pregl’s prize of National Institute of Chemistry. From 2013 his research activities comprise investigation of non-canonical structures and their interaction with small organic molecules and ions. In this regard, his work contributed to better understanding of principles governing G-quadruplex self-assembly and provided insights into specific structural motifs addressing the role of G-rich DNA in biological process, nanotechnology and medical applications.
Research interests:
• Folding and structural details of non-canonical nucleic acid structures
• Structures of nucleic acid - organic molecule complexes, particularly the features at the interfaces
• Interactions between nucleic acid and cations
LIST OF PUBLICATIONS
2022
14
Q. Li, M. Trajkovski, C. Fan, J. Chen, Y. Zhou, K. Lu, H. Li, X. Su, Z. Xi, J. Plavec and C. Zhou
4′-SCF3 Labeling Constitutes a Sensitive 19F NMR Probe for the Characterization of Interactions in the Minor Groove of DNA
Angew. Chem. Int. Ed. 2022, 61 (47), e202201848.
Web access at Wiley Online Library
Angew. Chem. 2022, 134 (47), e202201848.
Web access at Wiley Online Library
13
A. Ghosh, M. Trajkovski, M.-P. Teulade-Fichou, V. Gabelica and J. Plavec
Phen-DC3 Induces Refolding of Human Telomeric DNA into in a Chair-Type Antiparallel G-Quadruplex through Ligand Intercalation
Angew. Chem. Int. Ed. 2022, 61 (40), e202207384.
Web access at Wiley Online Library
Angew. Chem. 2022, 134 (40), e202207384.
Web access at Wiley Online Library
2021
12
F. Guo, M. Trajkovski, Q. Li, J. Plavec, Z. Xi and C. Zhou
Synthesis and Structure of 4’-CF3 Modified Ribonucleotides
Chin. J. Org. Chem. 2021, 41 (10), 4059-4065.
Web access at SIOC Journals
2020
11
C. Platella, M. Trajkovski, F. Doria, M. Freccero, J. Plavec and D. Montesarchio
On the interaction of an anticancer trisubstituted naphthalene diimide with G-quadruplexes of different topologies: a structural insight
Nucleic Acids Res. 2020, 48 (21), 12380-12393.
Web access at Oxford Journals
10
Q. Li, J. Chen, M. Trajkovski, Y. Zhou, C. Fan, K. Lu, P. Tang, X. Su, J. Plavec, Z. Xi and C. Zhou
4′-Fluorinated RNA: Synthesis, Structure, and Applications as a Sensitive 19F NMR Probe of RNA Structure and Function
J. Am. Chem. Soc. 2020, 142 (10), 4739-4748.
Web access at ACS Publications
9
M. Trajkovski and J. Plavec
Chasing particularities of guanine- and cytosine-rich DNA strands
Molecules 2020, 25(3), 434.
Web access at MDPI
2019
8
M. M. Naeem, R. Maheshan, S. R. Costford, A. Wahedi, M. Trajkovski, J. Plavec, L. A. Yatsunyk, G. L. Ciesielski, B. A. Kaufman and N. Sondheimer
G-Quadruplex Mediated Reduction of a Pathogenic Mitochondrial Heteroplasmy
Hum. Mol. Genet. 2019, 28(19), 3163-3174.
Web access at Oxford Journals
2018
7
F. Guo, Z. Yue, M. Trajkovski, X. Zhou, D. Cao, Q. Li, B. Wang, X. Wen, J. Plavec, Q. Peng, Z. Xi and C. Zhou
Effect of Ribose Conformation on RNA Cleavage via Internal Transesterification
J. Am. Chem. Soc. 2018, 140 (38), 11893-11897.
Web access at ACS Publications
6
M. Trajkovski, T. Endoh, H. Tateishi-Karimata, T. Ohyama, S. Tanaka, J. Plavec and N. Sugimoto
Pursuing origins of (poly)ethylene glycol-induced G-quadruplex structural modulations
Nucleic Acids Res. 2018, 46 (8), 4301-4315.
Web access at Oxford Journals
2015
5
M. Trajkovski, E. Morel, F. Hamon, S. Bombard, M.-P. Teulade-Fichou and J. Plavec
Interactions of Pt-ttpy with G-quadruplexes originating from promoter region of the c-myc gene deciphered by NMR and gel electrophoresis analysis
Chem. Eur. J. 2015, 21 (21), 7798–7807.
Web access at Wiley Online Library
2012
4
M. Trajkovski and J. Plavec
Assessing Roles Of Cations In G-quadruplex Based Nanowires By NMR
J. Phys. Chem. C 2012, 116 (44), 23821-23825.
Web access at ACS publications
3
M. Trajkovski, M. Webba da Silva and J. Plavec
Unique Structural Features of Interconverting Monomeric and Dimeric G-Quadruplexes Adopted by a Sequence from the Intron of the N-myc Gene
J. Am. Chem. Soc. 2012, 134 (9), 4132–4141.
Web access at ACS Publications
2009
2
M. Webba da Silva, M. Trajkovski, Y. Sannohe, N. M. Hessari, H. Sugiyama and J. Plavec
Design of a G-Quadruplex Topology through Glycosidic Bond Angles
Angew. Chem. Int. Edit. 2009, 48 (48), 9167-9170.
1
M. Trajkovski, P. Sket and J. Plavec
Cation Localization and Movement within DNA Thrombin Binding Aptamer in Solution
Org. Biomol. Chem. 2009, 7 (22), 4677-4684.